Flexing Culture Membrane Bioreactor for Trinity College Dublin

Description

A computer-controlled bioreactor is required capable of applying cyclic or static tensile strains to cells cultured in vitro using regulated vacuum and positive air pressure. The system should be capable of simulating in vivo tissue strains and frequencies to cells from muscle, lung, heart, bone, blood vessels and tendon. Multiple frequency, amplitude and waveform changes must be able to be programmed in one regimen with waveforms ranging from static, sinusoidal, cardiac, triangular, square and some custom waveforms. Should be suitable for a standard 6-well cell culture plate configuration with the option to actuate more than one well-plate simultaneously. A computer-controlled bioreactor is required capable of applying cyclic or static tensile strains to cells cultured in vitro using regulated vacuum and positive air pressure. The system should be capable of simulating in vivo tissue strains and frequencies to cells from muscle, lung, heart, bone, blood vessels and tendon. Multiple frequency, amplitude and waveform changes must be able to be programmed in one regimen with waveforms ranging from static, sinusoidal, cardiac, triangular, square and some custom waveforms. Should be suitable for a standard 6-well cell culture plate configuration with the option to actuate more than one well-plate simultaneously.