Elyra 7

Description

With the recently developed Lattice SIM2 technology, there is a clear opportunity to broadly deploy SR at the new Institute for Regeneration and Repair (IRR) at the Edinburgh bioQuarter campus. Our ability to track dynamic cellular processes has been transformed by new tools and techniques that have emerged from genetics (CRISPR), stem cell biology (iPSCs and organoids), and synthetic biology (genetic circuits and reporters). These can be combined with super-resolution (SR) imaging capabilities to gain deep mechanistic insights into human disease mechanisms and support drug discovery (target validation). We are therefore seeking support to purchase the Zeiss Lattice SIM2 SR microscope. This will open possibilities for many MRC funded research groups to routinely perform live cell super-resolution imaging across a range of physiological samples, scales and models. Zeiss Lattice SIM2 SR microscope. This will open possibilities for many research groups to routinely perform live cell super-resolution imaging across a range of physiological samples, scales and models. The procurement route taken is a direct award facilitated through APUC frameworks. Stem cell biology and regenerative medicine have been a strategic priority for the UoE over the past two decades. Newly recruited faculty at all career stages have created a critical mass of PIs who have, and continue, to make seminal contributions to our understanding of fundamental biology and translation into new technologies, platforms and therapeutics. The new Institute for Regeneration and Repair (IRR) at the Edinburgh bioQuarter campus, brings together faculty from the former MRC Centre for Regenerative Medicine, MRC Centre for Inflammation Research and MRC Centre for Reproductive Health. Over the past decade these MRC Centres have created a wealth of novel stem cell-based models, genetically engineered derivative cell reporters, model organisms (development, regeneration/repair and cancer), as well as human tissue slice techniques, co-cultures